Is Melatonin Safe? New Study Links Long-Term Use to Heart Health Risks (2025)

Worried about your heart health? A recent study suggests that something many people consider a harmless sleep aid – melatonin – might actually pose a risk, particularly with long-term use. This news comes from a report by the American Heart Association, and it's something everyone should pay attention to.

Catch the 'Decision Desk 2025' special coverage of nationwide elections on NewsNation this Tuesday, live from 7 p.m. to 12 a.m. EST. Hosted by Chris Cuomo, Elizabeth Vargas, Leland Vittert, and Chris Stirewalt, along with a panel of bipartisan political guests. If you're unsure how to find NewsNation, use their Channel Finder or log in to their website's live player.

So, what's the buzz about melatonin? Well, it's a popular supplement often used to combat insomnia and promote sleep. It's frequently marketed as a safe, natural alternative. But here's where it gets controversial: researchers have found a potential link between its long-term use and an increased risk of heart failure hospitalization.

The study, which analyzed five years of health records from over 130,000 adults with insomnia, is quite eye-opening. Roughly 65,000 of these individuals had a documented history of long-term melatonin use (defined as one year or more). The remaining participants had no record of melatonin use. Patients with existing heart failure or those taking other sleep medications were excluded to ensure the most accurate results.

And this is the part most people miss: The findings revealed that over the five-year period, those with insomnia who used melatonin long-term had a higher likelihood of experiencing heart failure compared to non-users. Even after accounting for various risk factors and health conditions, the association between prolonged melatonin use and serious cardiovascular outcomes remained significant.

Lead researcher Nnadi stated, "Melatonin is generally viewed as a very safe supplement…so we honestly didn’t expect to see a clear signal linking long-term use with higher rates of heart failure, hospitalizations, and death." This statement highlights how unexpected these findings were, especially since melatonin is so widely used.

It's important to note that the study hasn't been peer-reviewed yet, and experts are urging caution against immediate alarm. The lead researcher also clarified that the study cannot definitively prove a direct cause-and-effect relationship, emphasizing the need for further research to fully understand melatonin's impact on heart health.

However, the study isn't without its limitations. For instance, over-the-counter melatonin use might not always be captured in medical records, potentially leading to some non-users actually taking the supplement. Additionally, the study lacked detailed data on insomnia severity and psychiatric conditions, which could have influenced the results.

Heart failure, a condition where the heart struggles to pump enough blood, affects a staggering 6.7 million adults in the U.S., according to the 2025 Heart Disease and Stroke Statistics.

What are your thoughts on this? Do these findings change your perspective on melatonin? Share your opinions in the comments below – let's discuss!

Is Melatonin Safe? New Study Links Long-Term Use to Heart Health Risks (2025)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Ray Christiansen

Last Updated:

Views: 5828

Rating: 4.9 / 5 (69 voted)

Reviews: 92% of readers found this page helpful

Author information

Name: Ray Christiansen

Birthday: 1998-05-04

Address: Apt. 814 34339 Sauer Islands, Hirtheville, GA 02446-8771

Phone: +337636892828

Job: Lead Hospitality Designer

Hobby: Urban exploration, Tai chi, Lockpicking, Fashion, Gunsmithing, Pottery, Geocaching

Introduction: My name is Ray Christiansen, I am a fair, good, cute, gentle, vast, glamorous, excited person who loves writing and wants to share my knowledge and understanding with you.